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Progestin in the form of megestrol acetate (Ovaban) is used
to postpone heat cycles in dogs and as a treatment for false pregnancy.
It has also been used to treat certain skin conditions in cats.
Because of its severe side effects, and the availablity of other
therapies, Ovaban should only be used as a last resort. Contact
your veterinarian if your pet experiences increased thirst or
urination, depression, mammary gland enlargement, temperament
changes, vaginal discharge, vomiting, or yellow gums while being
treated with Ovaban.
Type of Drug
Form and Storage
Store at room temperature.
Indication for Use
Used to postpone estrus (female's heat cycle) and help end a false pregnancy.
Megestrol acetate is FDA approved for use in dogs. Available by prescription. This medication is not used as frequently due to development of newer and safer medications; it is prescribed with utmost caution. Progesterone and other progestins are produced by the female's ovaries and by the placenta. They regulate "heat" cycles, prepare the body for pregnancy, maintain pregnancy, and stimulate milk production. Progestins have the opposite effect as testosterone, and they have been used without FDA approval to reduce male sexual behaviors including fighting, roaming, inappropriate mounting, and other behaviors. Need to use behavior training at the same time. Other treatments including neutering and behavior training are preferred due to the potential side effects of the medication. Progestins have also been used to treat types of inflammation and immune-mediated diseases although corticosteroids are preferred if they work. Megestrol acetate is used in cats for treatment of behavior problems.
Usual Dose and Administration
Estrus suppression: depends on stage of cycle when start. Consult your veterinarian. Best results if start within first 3 days of proestrus. Treatment of false pregnancy: given daily for 8 days. Consult your veterinarian for dose. Pills may be given whole or crushed and given with food.
May see mammary enlargement or tumors; milk production; listlessness; increased appetite, thirst, and urination; bone marrow suppression; temperament changes; or uterine changes including pyometra (infection) and infertility. Cats may develop Addison's disease, diabetes, or liver damage.
Drug or Food Interactions
No specific information is available. Contact your veterinarian or the Animal Poison Control Center if you think your pet may have accidentally received or been given an overdose of the medication.
The information on this page was obtained from the site www.peteducation.com